Shaping faces: genetic and epigenetic control of craniofacial morphogenesis
Major differences in facial morphology distinguish vertebrate species. Variation of facial
traits underlies the uniqueness of human individuals, and abnormal craniofacial …
traits underlies the uniqueness of human individuals, and abnormal craniofacial …
Shared heritability of human face and brain shape
Evidence from model organisms and clinical genetics suggests coordination between the
developing brain and face, but the role of this link in common genetic variation remains …
developing brain and face, but the role of this link in common genetic variation remains …
Association of maternal diabetes with neurodevelopmental disorders: autism spectrum disorders, attention-deficit/hyperactivity disorder and intellectual disability
S Chen, S Zhao, C Dalman, H Karlsson… - International journal …, 2021 - academic.oup.com
Background Maternal diabetes has been associated with a risk of neurodevelopmental
disorders (NDDs) in offspring, though the common co-occurrence of autism spectrum …
disorders (NDDs) in offspring, though the common co-occurrence of autism spectrum …
[HTML][HTML] Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review
The primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) has a prominent role in
regulating neural development and function, with disruption to GABAergic signalling linked …
regulating neural development and function, with disruption to GABAergic signalling linked …
Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN
Germline mutations in PTEN, the gene that encodes phosphatase and tensin homolog, have
been identified in up to 20% of children with autism spectrum disorder (ASD) and …
been identified in up to 20% of children with autism spectrum disorder (ASD) and …
Prenatal environmental stressors impair postnatal microglia function and adult behavior in males
CL Block, O Eroglu, SD Mague, CJ Smith, AM Ceasrine… - Cell reports, 2022 - cell.com
Gestational exposure to environmental toxins and socioeconomic stressors is
epidemiologically linked to neurodevelopmental disorders with strong male bias, such as …
epidemiologically linked to neurodevelopmental disorders with strong male bias, such as …
Genetic neurodevelopmental clustering and dyslexia
A Ciulkinyte, HS Mountford, P Fontanillas… - Molecular …, 2024 - nature.com
Dyslexia is a learning difficulty with neurodevelopmental origins, manifesting as reduced
accuracy and speed in reading and spelling. It is substantially heritable and frequently co …
accuracy and speed in reading and spelling. It is substantially heritable and frequently co …
Childhood adversity, mental health, and oxidative stress: a pilot study
Childhood adversity is a potent risk factor for mental health conditions via disruptions to
stress response systems. Dysregulations in oxidative stress systems have been associated …
stress response systems. Dysregulations in oxidative stress systems have been associated …
[HTML][HTML] Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
DC Beard, X Zhang, DY Wu, JR Martin, A Erickson… - Cell reports, 2023 - cell.com
Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from
differential severity of variants underlying disease, but how distinct alleles drive variable …
differential severity of variants underlying disease, but how distinct alleles drive variable …
Foxp1 in forebrain pyramidal neurons controls gene expression required for spatial learning and synaptic plasticity
DJ Araujo, K Toriumi, CO Escamilla… - Journal of …, 2017 - Soc Neuroscience
Genetic perturbations of the transcription factor Forkhead Box P1 (FOXP1) are causative for
severe forms of autism spectrum disorder that are often comorbid with intellectual disability …
severe forms of autism spectrum disorder that are often comorbid with intellectual disability …