A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

Bronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is
characterized by airflow limitation and an obstructive spirometric pattern without high …

Long-term survival after lung transplantation remains suboptimal due to chronic lung
allograft dysfunction (CLAD), a progressive scarring process affecting the graft. Although anti …

BACKGROUND Chronic lung allograft dysfunction (CLAD) is a heterogeneous condition.
Characterization of CLAD phenotypes is essential to enhance the understanding of …

Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant
recipients. CLAD is characterized clinically by a persistent decline in pulmonary function and …

BACKGROUND The complement system plays a key role in host defense but is activated by
ischemia/reperfusion injury (IRI). Primary graft dysfunction (PGD) is a form of acute lung …

Early diagnosis of drug-induced liver injury (DILI) continues to be a major hurdle during drug
development and postmarketing. The objective of this study was to evaluate the diagnostic …

Transplanted lungs suffer worse outcomes than other organ transplants with many
developing chronic lung allograft dysfunction (CLAD), diagnosed by physiologic changes …

Background Many lung transplants fail due to chronic lung allograft dysfunction (CLAD). We
recently showed that transbronchial biopsies (TBBs) from CLAD patients manifest severe …

Background Airway epithelial injury is thought to be a key event in the pathogenesis of
chronic lung allograft dysfunction (CLAD). We investigated whether markers of epithelial …