Importance of prophages to evolution and virulence of bacterial pathogens

LC Fortier, O Sekulovic - Virulence, 2013 - Taylor & Francis
Bacteriophages, or simply phages, are viruses infecting bacteria. With an estimated 1031
particles in the biosphere, phages outnumber bacteria by a factor of at least 10 and not …

Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion

H Brüssow, C Canchaya… - … and molecular biology …, 2004 - Am Soc Microbiol
Comparative genomics demonstrated that the chromosomes from bacteria and their viruses
(bacteriophages) are coevolving. This process is most evident for bacterial pathogens where …

Standardized bacteriophage purification for personalized phage therapy

T Luong, AC Salabarria, RA Edwards, DR Roach - Nature protocols, 2020 - nature.com
The world is on the cusp of a post-antibiotic era, but researchers and medical doctors have
found a way forward—by looking back at how infections were treated before the advent of …

Identification and characterization of a novel botulinum neurotoxin

S Zhang, G Masuyer, J Zhang, Y Shen, D Lundin… - Nature …, 2017 - nature.com
Botulinum neurotoxins are known to have seven serotypes (BoNT/A–G). Here we report a
new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with …

Ecological and evolutionary benefits of temperate phage: what does or doesn't kill you makes you stronger

E Harrison, MA Brockhurst - BioEssays, 2017 - Wiley Online Library
Infection by a temperate phage can lead to death of the bacterial cell, but sometimes these
phages integrate into the bacterial chromosome, offering the potential for a more long …

Prophage genomics

C Canchaya, C Proux, G Fournous… - Microbiology and …, 2003 - Am Soc Microbiol
The majority of the bacterial genome sequences deposited in the National Center for
Biotechnology Information database contain prophage sequences. Analysis of the …

The Regulatory Networks That Control Clostridium difficile Toxin Synthesis

I Martin-Verstraete, J Peltier, B Dupuy - Toxins, 2016 - mdpi.com
The pathogenic clostridia cause many human and animal diseases, which typically arise as
a consequence of the production of potent exotoxins. Among the enterotoxic clostridia …

Phage therapy: facts and fiction

M Skurnik, E Strauch - International Journal of Medical Microbiology, 2006 - Elsevier
Recent examples of the use of bacteriophages in controlling bacterial infections are
presented, some of which show therapeutic promise. The therapeutic use of bacteriophages …

Application of bacteriophages for detection and control of foodborne pathogens

S Hagens, MJ Loessner - Applied microbiology and biotechnology, 2007 - Springer
The incidence of foodborne infectious diseases is stable or has even increased in many
countries. Consequently, our awareness regarding hygiene measures in food production …

When a virus is not a parasite: the beneficial effects of prophages on bacterial fitness

J Bondy-Denomy, AR Davidson - Journal of microbiology, 2014 - Springer
Most organisms on the planet have viruses that infect them. Viral infection may lead to cell
death, or to a symbiotic relationship where the genomes of both virus and host replicate …