The role of astrocytes in CNS inflammation

F Giovannoni, FJ Quintana - Trends in immunology, 2020 - cell.com
Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …

Beyond the GFAP-astrocyte protein markers in the brain

AM Jurga, M Paleczna, J Kadluczka, KZ Kuter - Biomolecules, 2021 - mdpi.com
The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

Targeting neuroinflammation in Alzheimer's disease: From mechanisms to clinical applications

ZZ Si, CJ Zou, X Mei, XF Li, H Luo, Y Shen… - Neural regeneration …, 2023 - journals.lww.com
Alzheimer's disease is characterized by sustained neuroinflammation leading to memory
loss and cognitive decline. The past decade has witnessed tremendous efforts in …

Neuroinflammation during RNA viral infections

RS Klein, C Garber, KE Funk, H Salimi… - Annual review of …, 2019 - annualreviews.org
Neurotropic RNA viruses continue to emerge and are increasingly linked to diseases of the
central nervous system (CNS) despite viral clearance. Indeed, the overall mortality of viral …

Immune players in the CNS: the astrocyte

CJ Jensen, A Massie, J De Keyser - Journal of Neuroimmune …, 2013 - Springer
In the finely balanced environment of the central nervous system astrocytes, the most
numerous cell type, play a role in regulating almost every physiological system. First found …

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects

R Lindqvist, F Mundt, JD Gilthorpe, S Wölfel… - Journal of …, 2016 - Springer
Background Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese
encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents …

Immune functions of astrocytes in viral neuroinfections

J Jorgačevski, M Potokar - International Journal of Molecular Sciences, 2023 - mdpi.com
Neuroinfections of the central nervous system (CNS) can be triggered by various pathogens.
Viruses are the most widespread and have the potential to induce long-term neurologic …

Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

A Licht-Murava, SM Meadows, F Palaguachi… - Science …, 2023 - science.org
Transactivating response region DNA binding protein 43 (TDP-43) pathology is prevalent in
dementia, but the cell type–specific effects of TDP-43 pathology are not clear, and …

[HTML][HTML] Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine

Y He, S Liu, S Leone, DS Newburg - Mucosal immunology, 2014 - Elsevier
The immature neonatal intestinal immune system hyperreacts to newly colonizing unfamiliar
bacteria. The hypothesis that human milk oligosaccharides from colostrum (cHMOSs) can …

Astrocytes: heterogeneous and dynamic phenotypes in neurodegeneration and innate immunity

C Cunningham, A Dunne… - The …, 2019 - journals.sagepub.com
Astrocytes are the most numerous cell type in the brain and perform several essential
functions in supporting neuronal metabolism and actively participating in neural circuit and …