Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens

E Peterson, P Kaur - Frontiers in microbiology, 2018 - frontiersin.org
Emergence of antibiotic resistant pathogenic bacteria poses a serious public health
challenge worldwide. However, antibiotic resistance genes are not confined to the clinic; …

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Antibiotic resistance mechanisms in M. tuberculosis: an update

L Nguyen - Archives of toxicology, 2016 - Springer
Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance–Forming Modification

M Oldenburg, A Krüger, R Ferstl, A Kaufmann, G Nees… - Science, 2012 - science.org
Host protection from infection relies on the recognition of pathogens by innate pattern-
recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan …

A Novel Gene, erm(41), Confers Inducible Macrolide Resistance to Clinical Isolates of Mycobacterium abscessus but Is Absent from Mycobacterium chelonae

KA Nash, BA Brown-Elliott… - Antimicrobial agents and …, 2009 - Am Soc Microbiol
Mycobacterium abscessus infections tend to respond poorly to macrolide-based
chemotherapy, even though the organisms appear to be susceptible to clarithromycin …

Resistance to macrolide antibiotics in public health pathogens

C Fyfe, TH Grossman… - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal
RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's …

Molecular Biology of Drug Resistance in Mycobacterium tuberculosis

T Smith, KA Wolff, L Nguyen - … tuberculosis and its Interaction with the …, 2012 - Springer
Tuberculosis (TB) has become a curable disease, thanks to the discovery of antibiotics.
However, it has remained one of the most difficult infections to treat. Most current TB …

Assessment of Clarithromycin Susceptibility in Strains Belonging to the Mycobacterium abscessus Group by erm(41) and rrl Sequencing

S Bastian, N Veziris, AL Roux, F Brossier… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Clarithromycin was the drug of choice for Mycobacterium abscessus infections until
inducible resistance due to erm (41) was described. Because M. abscessus was split into M …

New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria

MJ Nasiri, M Haeili, M Ghazi, H Goudarzi… - Frontiers in …, 2017 - frontiersin.org
Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …

Ancestral antibiotic resistance in Mycobacterium tuberculosis

RP Morris, L Nguyen, J Gatfield… - Proceedings of the …, 2005 - National Acad Sciences
Chemotherapeutic options to treat tuberculosis are severely restricted by the intrinsic
resistance of Mycobacterium tuberculosis to the majority of clinically applied antibiotics …