Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Atherosclerosis is a complex and multifactorial process, characterized by early …

Lung cancer is one of the most common causes of cancer-related mortality in the 21st
century. Statins as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase not only …

Background In randomized clinical trials statins and placebo treated patients showed the
same degree of coronary artery calcium (CAC) progression. We reanalyzed data from two …

Background: The intrinsic risk factors of rotator cuff disease (RCD) include degeneration,
inflammation, oxidative stress, and circulation impairment. Both diabetes and hyperlipidemia …

Lycopene is a carotenoid with known antioxidant and anti-inflammatory properties. We
aimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox …

Short-term cigarette smoke (CS) exposure does not cause emphysema; however, some
pathogenesis hallmarks are maintained, such as oxidative stress and inflammation. This …

Simvastatin (SIM) is anti-inflammatory. We used low density lipoprotein receptor knockout
(LDLR-/-) mice and human aortic smooth muscle cells (HASMCs) as model systems to study …

Contrast-induced acute kidney injury (CI-AKI) is a common complication of iodinated
contrast medium administration during cardiac catheterization. Statin treatment has been …

The use of annatto pigments has been evaluated as a therapeutic strategy in animal models
of several health disorders. Beneficial effects were generally attributed to the inhibition of …

Objectives: To systematically review the evidence on whether statin therapy, commonly used
in clinical practice to treat hypercholesterolaemia for primary and secondary prevention of …