We review drug conjugates combining a tumor-selective moiety with a cytotoxic agent as
cancer treatments. Currently, antibody-drug conjugates (ADCs) are the most common drug …

Gene delivery has revolutionized conventional medical approaches to vaccination, cancer,
and autoimmune diseases. However, current gene delivery methods are limited to either …

Non-small cell lung cancer (NSCLC) is a highly lethal disease and the majority of NSCLC
patients are desperate for therapies that can effectively target their cancer and ultimately …

Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …

Breast cancer is the most common and deadliest cancer in women worldwide. Although
notable advances have been achieved in the treatment of breast cancer, the overall survival …

Various nanomaterials have recently become fascinating tools in cancer diagnostic
applications because of their multifunctional and inherent molecular characteristics that …

Purpose Maytansine (DM1) is a potent anticancer drug and limited in clinical application due
to its poor water solubility and toxic side effects. Zein is widely used in nano drug delivery …

Proteolysis-targeting chimeras (PROTACs) are an emerging class of promising therapeutic
molecules that can target specific disease-related proteins and then degrade them by the …

Understanding the molecular mechanisms of cancer biology introduces targeted therapy as
a complementary method along with other conventional therapies. Recombinant …

Affibody molecules are small non-immunoglobulin affinity proteins, which can precisely
target to some cancer cells with specific overexpressed molecular signatures. However, the …