Biosynthetic strategies of berberine bridge enzyme-like flavoprotein oxidases toward structural diversification in natural product biosynthesis
G Tjallinks, A Mattevi, MW Fraaije - Biochemistry, 2024 - ACS Publications
Berberine bridge enzyme-like oxidases are often involved in natural product biosynthesis
and are seen as essential enzymes for the generation of intricate pharmacophores. These …
and are seen as essential enzymes for the generation of intricate pharmacophores. These …
Sustainable metabolic engineering requires a perfect trifecta
Highlights•Advances in biotechnology unlock access to chemical diversity and natural
products.•Metabolic engineering enables the discovery and production of new-to-nature …
products.•Metabolic engineering enables the discovery and production of new-to-nature …
Generation of Alternate Indole Diterpene Architectures in Two Species of Aspergilli
R Bundela, RC Cameron, AJ Singh… - Journal of the …, 2023 - ACS Publications
The significant structural diversity and potent bioactivity of the fungal indole diterpenes
(IDTs) has attracted considerable interest in their biosynthesis. Although substantial skeletal …
(IDTs) has attracted considerable interest in their biosynthesis. Although substantial skeletal …
Functional Crosstalk between Discrete Indole Terpenoid Gene Clusters in Tolypocladium album
TR Hibbard, RM McLellan, LJ Stevenson… - Organic …, 2023 - ACS Publications
Indole terpenoids make up a large group of secondary metabolites that display an enticing
array of bioactivities. While indole diterpene (IDT) and rarely indole sesquiterpene (IST) …
array of bioactivities. While indole diterpene (IDT) and rarely indole sesquiterpene (IST) …
Biochemical characterization of a multiple prenyltransferase from Tolypocladium inflatum
H Han, S Peng, Q Wang, H Wang, P Wang, C Li… - Applied Microbiology …, 2024 - Springer
Prenylation plays a pivotal role in the diversification and biological activities of natural
products. This study presents the functional characterization of TolF, a multiple …
products. This study presents the functional characterization of TolF, a multiple …
Oxidative bicyclic ring system formation involving indole diterpene biosynthesis: remarkable substrate tolerance of a prenyltransferase and flavoprotein oxidase
Y Liu, T Ozaki, A Minami, H Oikawa - Tetrahedron Letters, 2023 - Elsevier
Oxidative modifications are key biosynthetic processes responsible for expanding the
structural diversity of indole diterpenes (IDTs). In this study, we focused on the function of …
structural diversity of indole diterpenes (IDTs). In this study, we focused on the function of …