Target of rapamycin complex 1 (TORC1) is an important regulator of various signaling
pathways. It can control cell growth and development by integrating multiple signals from …

The survival of eukaryotic organisms during environmental changes is largely dependent on
the adaptive responses elicited by signal transduction cascades, including those regulated …

Nutrient-sensitive phosphorylation of the S6 protein of the 40S subunit of the eukaryote
ribosome is highly conserved. However, despite four decades of research, the functional …

General autophagy is an evolutionarily conserved process in eukaryotes, by which
intracellular materials are transported into and degraded inside lysosomes or vacuoles, with …

The target of rapamycin complex 1 (TORC1) is an evolutionarily conserved sensor of
nutrient availability. Genetic and pharmacological studies in the yeast Saccharomyces …

The target of rapamycin (TOR) protein kinase forms multi-subunit TOR complex 1 (TORC1)
and TOR complex 2 (TORC2), which exhibit distinct substrate specificities. Sin1 is one of the …

Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex
composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive …

In Schizosaccharomyces pombe, ecl family genes are induced by several signals, such as
starvation of various nutrients, including sulfur, amino acids and Mg2+, and environmental …

Abstract tRNA isopentenyltransferases (Tit1) modify tRNA position 37, adjacent to the
anticodon, to N 6-isopentenyladenosine (i6A37) in all cells, yet the tRNA subsets selected …

Target of rapamycin (TOR) kinase controls cell metabolism and growth in response to
environmental cues such as nutrients, growth factors, and stress. TOR kinase is widely …