Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes
mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death …

Blood glucose concentrations are controlled by a loop incorporating two components, the
beta cells which secrete insulin and the insulin-sensitive tissues (liver, muscle, adipose) …

Apoptotic cell death in pancreatic β-cells is involved in the pathogenesis of diabetes. Signals
from death receptors and DNA damage have been widely accepted as being triggers of …

The physiological performance of an organ depends on an interplay between changes in
cellular function and organ size, determined by cell growth, proliferation and death …

Nutrition science has evolved considerably in the past decade with new concepts and
discoveries. In response, advanced nutrition courses now encompass material on …

Stress conditions and proinflammatory cytokines activate the c-Jun NH2-terminal kinase
(JNK), a member of the stress-activated group of mitogen-activated protein kinases …

Inflammatory infiltrate of mononuclear cells in an islet from a 2-yearold patient with type 1
diabetes of short duration. Mononuclear cells in and around islets are shown by yellow …

Among its pleiotropic actions, ghrelin modulates insulin secretion and glucose metabolism.
Herein we investigated the role of ghrelin in pancreatic β-cell proliferation and apoptosis …

We investigated the effect of a chronic exposure to high levels of free fatty acid (FFA; 2
mmol/L oleate/palmitate 2: 1) or glucose (16.7 mmol/L) on islet cell apoptosis. Apoptosis was …

Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets
of Langerhans, followed by the selective and progressive destruction of insulin-secreting …