Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview

W Brack, S Ait-Aissa, RM Burgess, W Busch… - Science of the Total …, 2016 - Elsevier
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …

Diagnosis of complex mixture toxicity in sediments: Application of toxicity identification evaluation (TIE) and effect-directed analysis (EDA)

H Li, J Zhang, J You - Environmental Pollution, 2018 - Elsevier
Determining causality of sediment toxicity is of great importance in aquatic risk assessment,
but there are tremendous challenges due to joint toxicity of trace pollutants in complex …

[HTML][HTML] Assessment of a novel device for onsite integrative large-volume solid phase extraction of water samples to enable a comprehensive chemical and effect …

T Schulze, M Ahel, J Ahlheim, S Aït-Aïssa… - Science of the total …, 2017 - Elsevier
The implementation of targeted and nontargeted chemical screening analysis in
combination with in vitro and organism-level bioassays is a prerequisite for a more holistic …

Direct coupling of thin-layer chromatography with a bioassay for the detection of estrogenic compounds: applications for effect-directed analysis

S Buchinger, D Spira, K Bröder… - Analytical …, 2013 - ACS Publications
The present study investigated the hypothesis that the coupling of high-performance thin-
layer chromatography with the yeast estrogen screen (planar-YES, p-YES) can be used as a …

Mutagenicity in surface waters: synergistic effects of carboline alkaloids and aromatic amines

M Muz, M Krauss, S Kutsarova… - … science & technology, 2017 - ACS Publications
For decades, mutagenicity has been observed in many surface waters with a possible link to
the presence of aromatic amines. River Rhine is a well-known example of this phenomenon …

Assessing the genotoxic potential of freshwater sediments after extensive rain events–lessons learned from a case study in an effluent-dominated river in Germany

A Shuliakevich, M Muz, J Oehlmann, L Nagengast… - Water research, 2022 - Elsevier
Wastewater treatment plant effluents and releases from rainwater overflow basins can
contribute to the input of genotoxic micropollutants in aquatic ecosystems. Predominantly …

Assessing endocrine disruption in freshwater fish species from a “hotspot” for estrogenic activity in sediment

AK Müller, N Markert, K Leser, D Kämpfer… - Environmental …, 2020 - Elsevier
Little is known about sediment-bound exposure of fish to endocrine disrupting chemicals
(EDC) under field conditions. This study aimed to investigate potential routes of EDC …

Bioavailability and impacts of estrogenic compounds from suspended sediment on rainbow trout (Oncorhynchus mykiss)

AK Müller, N Markert, K Leser, D Kämpfer, S Schiwy… - Aquatic toxicology, 2021 - Elsevier
Numerous environmental pollutants have the potential to accumulate in sediments, and
among them are endocrine-disrupting chemicals (EDCs). It is well documented that water …

Effect directed analysis and mixture effects of estrogenic compounds in a sediment of the river Elbe

S Schmitt, G Reifferscheid, E Claus… - … Science and Pollution …, 2012 - Springer
Abstract Introduction Endocrine disrupting chemicals (EDCs) are present in the environment
and can have serious effects on humans and wildlife. For the establishment of …

In vitro genotoxicity testing: significance and use in environmental monitoring

GDA Umbuzeiro, M Heringa, E Zeiger - In vitro Environmental Toxicology …, 2017 - Springer
There is ongoing concern about the consequences of mutations in humans and biota arising
from environmental exposures to industrial and other chemicals. Genetic toxicity tests have …