As vaccine formulations have progressed from including live or attenuated strains of
pathogenic components for enhanced safety, developing new adjuvants to more effectively …

Vaccines are the most effective means of controlling infectious diseases. Increasingly
epidemics have driven the development of vaccines for human use. However, insufficient …

A progressive loss of neuronal structure and function is a signature of many
neurodegenerative conditions including chronic traumatic encephalopathy, Parkinson's …

Background Influenza (flu) is a constant threat to humans and animals, and vaccination is
one of the most effective ways to mitigate the disease. Due to incomplete protection induced …

Mucosal surfaces represent important routes of entry into the human body for the majority of
pathogens, and they constitute unique sites for targeted vaccine delivery. Nanoparticle …

Complex biological barriers are major obstacles for preventing and treating disease.
Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through …

We have recently demonstrated the effectiveness of an influenza A virus (IAV) subunit
vaccine based on biodegradable polyanhydride nanoparticles delivery in mice. In the …

Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) causes Johne's
disease in ruminants and is characterized by chronic gastroenteritis leading to heavy …

Vaccine development has had a huge impact on human health. However, there is a
significant need to develop efficacious vaccines for several existing as well as emerging …

Adjuvant potential of positively charged corn-derived nanoparticles (Nano-11) was earlier
revealed in mice. We evaluated its adjuvant role to electrostatically adsorbed …