Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Statins, inhibitors of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase enzyme, are
molecules of fungal origin. By inhibiting a key step in the sterol biosynthetic pathway statins …

Background Global prescription drug use has been increasing continuously for decades.
The gut microbiome, a key contributor to health status, can be altered by prescription drug …

BACKGROUND In the acute respiratory distress syndrome (ARDS), inflammation in the
lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3 …

Conventional alloys and superalloys are useful in engineering, automotive, aerospace and
medical applications. However, some are affected by high temperature oxidation while …

Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …

In recent years, due to the dramatic increase in and global spread of bacterial resistance to a
number of commonly used antibacterial agents, many studies have been directed at …

The human gut microbiome is a complex microbial community that is strongly linked to both
host health and disease. However, the detailed molecular mechanisms underlying the …

Background Delirium is common in mechanically ventilated patients and is associated with
cognitive impairment lasting at least 1 year after hospital discharge. Preclinical and …

Clostridium (reclassified as “Clostridioides”) difficile infection (CDI) is a healthcare-
associated infection and significant source of potentially preventable morbidity, recurrence …