Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …

The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …

Synergy is a process in which some substances cooperate to reach a combined effect that is
greater than the sum of their separate effects. It can be considered a natural “straight” …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

The aim of this document is to provide evidence‐based recommendations for the medical
treatment of depression in adults with epilepsy. The working group consisted of members of …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Antiepileptic drugs (AEDs) are widely used as long-term adjunctive therapy or as
monotherapy in epilepsy and other indications and consist of a group of drugs that are …

Herbs are often administered in combination with therapeutic drugs, raising the potential of
herb-drug interactions. An extensive review of the literature identified reported herb-drug …

Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …

Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest
used and most extensively investigated medicinal herbs. The medicinal form comprises the …