Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …

BACKGROUND To provide the optimal milieu for implantation and fetal development, the
female reproductive system must orchestrate uterine dynamics with the appropriate …

Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …

Within the ovarian cancer tumor microenvironment, cancer stem-like cells (CSC) interact
with carcinoma associated mesenchymal stem/stromal cells (CA-MSC) through multiple …

Simple Summary The Warburg effect in cancer cells (high glucose update and lactate
release) is an adaptation that is considered a hallmark of most neoplasms. Blocking …

Successful preclinical drug testing relies in part on data generated using in vitro cell culture
models that recapitulate the structure and function of tumours and other tissues in vivo. The …

Traditional two-dimensional (2D) monolayer cell cultures have long been the gold standard
for cancer biology research. However, their ability to accurately reflect the molecular …

High-grade serous ovarian cancer (HGSOC) is the most frequent and aggressive type of
epithelial ovarian cancer, with high recurrence rate and chemoresistance being the main …

Ovarian cancer (OC) is one of the most lethal gynecologic malignancies. Due to the lack of
specific symptoms and screening methods, this disease is usually diagnosed only at an …

Simple Summary Ovarian cancer is one of the most lethal female cancers. Numerous
investigations into the development and progression of this disease have resulted in the …