The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

Nonalcoholic fatty liver disease (NAFLD) is a common, progressive liver disease that affects
up to one-quarter of the adult population worldwide. The clinical and economic burden of …

Aims Myocardial infarction (MI) triggers an intense inflammatory response that is associated
with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1β and IL-18 …

Many patients with symptoms and signs of heart failure have a left ventricular ejection
fraction≥ 50%, termed heart failure with preserved ejection fraction (HFpEF). HFpEF is a …

Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of
atherosclerosis and a significant risk factor for the development of cardiovascular events. In …

Background An enhanced inflammatory response predicts worse outcomes in heart failure
(HF). We hypothesized that administration of IL-1 (interleukin-1) receptor antagonist …

Cardiovascular diseases are the leading cause of death worldwide. Research in the last two
decades has emphasized the inflammatory process as a key component in the …

Cardiac fibroblasts (CF) are well-established as key regulators of extracellular matrix (ECM)
turnover in the context of myocardial remodelling and fibrosis. Recently, this cell type has …

With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …