Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

L Lin, Q Wu, F Lu, J Lei, Y Zhou, Y Liu, N Zhu… - Frontiers in …, 2023 - frontiersin.org
Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

AU Khan, A Khan, B Shal, S Khan, M Khan… - Phytotherapy …, 2023 - Wiley Online Library
Cancer is the leading cause of mortality and morbidity worldwide, and its cases are rapidly
increasing every year. Several factors contribute to the development of tumorigenesis …

Pulmonary delivery of curcumin and quercetin nanoparticles for lung cancer–Part 2: toxicity and endocytosis

CY Loo, D Traini, PM Young, T Parumasivam… - Journal of Drug Delivery …, 2023 - Elsevier
The delivery of polyphenol compounds via inhalation to treat lung cancer is attractive to
enable high drug concentration in the tumor cells. Although polyphenols such as curcumin …

Role of Ciminalum-4-thiazolidinone Hybrids in Molecular NF-κB Dependent Pathways

D Szlachcikowska… - International …, 2024 - pmc.ncbi.nlm.nih.gov
A range of hybrid molecules incorporating the ciminalum moiety in the thiazolidinone ring
demonstrate significant anticancer and antimicrobial properties. Therefore, the aim of our …

Salvirrane AF, six undescribed nordrimane sesquiterpene derivatives from Salvia castanea Diels f. tomentosa Stib and their cytotoxic activities

R Zhang, DD Wang, LY Tang, PX Ji, XM Li, ZF Guo… - Phytochemistry, 2024 - Elsevier
Six undescribed nordrimane sesquiterpene derivatives, salvirrane AF (1–6), were isolated
from the roots and rhizomes of Salvia castanea Diels f. tomentosa Stib. Comprehensive …

Oxidative stress, inflammation, dysfunctional redox homeostasis and autophagy cause age-associated diseases

P Sobhon, G Savedvanich… - Exploration of …, 2023 - explorationpub.com
Aging and age-associated diseases (AADs) are growing risk factors in societies worldwide.
During aging, there is an accumulation of excessive oxygen free radicals [reactive oxygen …

[HTML][HTML] Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its …

LI Pascual, L Luna, RE González, JE Ortiz… - Plants, 2024 - mdpi.com
Historically, botanical preparations have been used to improve human health. Their active
ingredients are influenced by multiple factors such as intraspecies variations, environmental …

The Cytotoxicity of Some Biologically Active Nano Compounds against Colon Cancer: Advanced Biochemical Analyses

AS El-Tabl, AAER Dawood, S Kolkaila, EH Mohamed… - TWIST, 2023 - twistjournal.net
Colorectal cancer is one of the most common cancers worldwide, and it is also one of the
major causes of mortality from cancer. Chemotherapy drugs are generally limited due to …

Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats

Y Sezgin, ES Bora, DB Arda, Y Uyanikgil… - Acta cirurgica …, 2024 - SciELO Brasil
Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with
adverse effects on the liver, including the development of fatty liver. This study aimed to …

Current and Future Cancer Chemoprevention Strategies

JF Santibanez, VH Villar, C Echeverria - Pharmaceutics, 2023 - mdpi.com
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in
2020 and ranking as the second-leading cause of death in economically developed …