The microenvironment within solid tumours can influence the metastatic dissemination of
tumour cells, and recent evidence suggests that poorly oxygenated (hypoxic) cells in primary …

Chloroquine (CQ) has a broad spectrum of pharmacological activities including anticancer
and anti-inflammatory, in addition to its well-known antimalarial activity. This very useful …

Background Radiotherapy occupies an essential position as one of the most significant
approaches for the clinical treatment of cancer. However, we cannot overcome the …

Tumor hypoxia commonly occurs in solid tumors, and correlates with metastasis. Current
cancer therapies are inefficient in curing metastatic disease. Herein, we examined effect of …

Purpose There is a need for adjuvant/neo-adjuvant treatment strategies to prevent
metastatic relapse in soft tissue sarcoma (STS). Tumor hypoxia is associated with a high-risk …

AG014699 was the first inhibitor of the DNA repair enzyme PARP-1 to enter clinical trial in
cancer patients. In addition to enhancing the cytotoxic effect of DNA-damaging …

Increasing drug infiltration by exerting tumor-specific retention and penetration is a key
aspect for antitumor nanomedicine design. Herein, we have developed a mussel adhesive …

Simple Summary Soft tissue sarcomas are uncommon and diverse solid tumors with high
risks that have a poor prognosis. Tumor microenvironment (TME) and hypoxia play critical …

INTRODUCTION: The overall goal of this study was to assess the utility of three-dimensional
magnetic resonance imaging (MRI) for monitoring the temporal and spatial development of …

Background: Despite high metastasis rates, adjuvant/neoadjuvant systemic therapy for
localised soft tissue sarcoma (STS) is not used routinely. Progress requires tailoring therapy …