Candidiasis is a common infection of the skin, oral cavity and esophagus, gastrointestinal
tract, vagina and vascular system of humans. Although most infections occur in patients who …

Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, in immunocompromised patients …

It is widely assumed that the ability of Candida albicans to switch between different
morphologies is required for pathogenesis. However, most virulence studies have used …

Candida albicans is the primary fungal pathogen of humans. Despite the need for novel
drugs to combat fungal infections [Sobel, JD (2000) Clin Infectious Dis 30: 652], antifungal …

Vulvovaginal candidiasis, caused primarily by Candida albicans, presents significant health
issues for women of childbearing age. As a polymorphic fungus, the ability of C. albicans to …

Candida albicans, the major human fungal pathogen, undergoes a reversible morphological
transition from single yeast cells to pseudohyphal and hyphal filaments (elongated cells …

Introduction: Targeting pathogenetic mechanisms, rather than essential processes,
represents a very attractive alternative for the development of new antibiotics. This may be …

Here, we review the'target-centric'genomic strategy to antimicrobial discovery and share our
perspective on identification, validation and prioritization of potential antimicrobial drug …

The outer layer of the Candida albicans cell wall is enriched in highly glycosylated
mannoproteins that are the immediate point of contact with the host and strongly influence …

Metabolic adaptation, and in particular the modulation of carbon assimilatory pathways
during disease progression, is thought to contribute to the pathogenicity of Candida …