Cell-free DNA methylation and transcriptomic signature prediction of pregnancies with adverse outcomes

G Del Vecchio, Q Li, W Li, S Thamotharan… - Epigenetics, 2021 - Taylor & Francis
Although analysis of maternal plasma cell-free content has been employed for screening of
genetic abnormalities within a pregnancy, limited attention has been paid to its use for the …

Cell-free placental DNA: What do we really know?

N Yuen, M Lemaire, SL Wilson - PLoS genetics, 2024 - journals.plos.org
Cell-free placental DNA (cfpDNA) is present in maternal circulation during gestation.
CfpDNA carries great potential as a research and clinical tool as it provides a means to …

Circulating Cell-Free DNA in Metabolic Diseases

A Pollastri, P Kovacs, M Keller - Journal of the Endocrine …, 2025 - academic.oup.com
Metabolic diseases affect a consistent part of the human population, leading to rising
mortality rates. This raises the need for diagnostic tools to monitor the progress of these …

Cell-free fetal DNA increases prior to labor at term and in a subset of preterm births

N Gomez-Lopez, R Romero, G Schwenkel… - Reproductive …, 2020 - Springer
Cell-free fetal DNA in the maternal circulation has been associated with the onset of labor at
term. Moreover, clinical studies have suggested that cell-free fetal DNA has value to predict …

cfGWAS reveal genetic basis of cell-free DNA features

H Zhu, Y Zhang, S Zeng, L Li, R Ou, X Zhang, Y Lin… - medRxiv, 2024 - medrxiv.org
cfDNA consists of degraded DNA fragments released into body fluids. Its genetic and
pathological information makes it useful for prenatal testing and early tumor detection …

Mismatch between obesogenic intrauterine environment and low‐fat postnatal diet may confer offspring metabolic advantage

S Kislal, W Jin, C Maesner… - Obesity science & …, 2021 - Wiley Online Library
Objective Mismatch between a depleted intrauterine environment and a substrate‐rich
postnatal environment confers an increased risk of offspring obesity and metabolic …

The influence of maternal obesity on cell-free fetal DNA and blood pressure regulation in pregnancies with hypertensive disorders

A Stupak, W Kwaśniewski, A Goździcka-Józefiak… - Medicina, 2021 - mdpi.com
Background and Objectives: obesity and blood pressure disorders are one of the main risk
factors for antenatal, intra, postpartum, and neonatal complications. In preeclampsia (PE) …

Plasma DNA and deoxyribonuclease are associated with glucose metabolism in healthy mice

K Kmeťová, J Čonka, J Janko, J Illés, O Uličná, P Celec - Plos one, 2022 - journals.plos.org
It is currently unknown why obesity leads in some patients to prediabetes and metabolic
syndrome. Microinflammation potentially caused by extracellular DNA is supposed to be …

[HTML][HTML] Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring

D Zhao, Y Liu, S Jia, Y He, X Wei, D Liu, W Ma… - Biomedicine & …, 2022 - Elsevier
Epidemiological studies show that obesity during pregnancy affects more than half of the
pregnancies in the developed countries and is associated with obstetric problems and poor …