Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs

X Liu, H Yang, Z Liu - International Immunopharmacology, 2022 - Elsevier
Paraquat poisoning is a severe health problem globally, particularly in developing countries.
Due to its severe toxicity, the mortality rate of paraquat poisoning is greatly higher than other …

Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice

Y Chen, Y Nie, Y Luo, F Lin, Y Zheng, G Cheng… - Food and Chemical …, 2013 - Elsevier
The present study evaluates protective effects of naringin against paraquat (PQ)-induced
acute lung injury (ALI) and pulmonary fibrosis in mice. Survival probability against PQ …

Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway

J Han, Z Zhang, S Yang, J Wang, X Yang… - Food and chemical …, 2014 - Elsevier
We attempted to determine whether betanin (from natural pigments) that has anti-oxidant
properties would be protective against paraquat-induced liver injury in Sprague–Dawley …

The relation between oxidative stress, inflammation, and neopterin in the paraquat-induced lung toxicity

M Toygar, I Aydin, M Agilli, FN Aydin… - Human & …, 2015 - journals.sagepub.com
Paraquat (PQ) is a well-known quaternary nitrogen herbicide. The major target organ in PQ
poisoning is the lung. Reactive oxygen species (ROS) and inflammation play a crucial role …

[HTML][HTML] Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro

ALM Ivan, MZ Campanini, RM Martinez… - … of Photochemistry and …, 2014 - Elsevier
Ultraviolet B (UVB) irradiation may cause oxidative stress-and inflammation-dependent skin
cancer and premature aging. Pyrrolidine dithiocarbamate (PDTC) is an antioxidant and …

Natural Antioxidant Betanin Protects Rats from Paraquat‐Induced Acute Lung Injury Interstitial Pneumonia

J Han, D Ma, M Zhang, X Yang… - BioMed Research …, 2015 - Wiley Online Library
The effect of betanin on a rat paraquat‐induced acute lung injury (ALI) model was
investigated. Paraquat was injected intraperitoneally at a single dose of 20 mg/kg body …

Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling …

M Liu, R Liu, H Wu, Y Li, M Su, M Dong… - … and Alternative Medicine, 2015 - Springer
Abstract Background Puerarin, extracted from Radix puerariae, was reported to ameliorate
airway inflammation, lung injury and lung fibrosis induced by paraquat (PQ) in mice …

Inhibitions of NF-κB and TNF-α Result in Differential Effects in Rats with Acute on Chronic Liver Failure Induced by d-Gal and LPS

F Yang, X Li, L Wang, L Wang, X Han, H Zhang… - Inflammation, 2014 - Springer
In this study, we induced an acute-on-chronic liver failure (ACLF) model by human serum
albumin (HSA), d-galactosamine (d-Gal) and lipopolysaccharide (LPS) in rats. Anti-TNF-α …

[HTML][HTML] Critical role of the CXCL10/CXC chemokine receptor 3 axis in promoting leukocyte recruitment and neuronal injury during traumatic optic neuropathy induced …

Y Ha, H Liu, S Zhu, P Yi, W Liu, J Nathanson… - The American Journal of …, 2017 - Elsevier
Traumatic optic neuropathy (TON) is an acute injury of the optic nerve secondary to trauma.
Loss of retinal ganglion cells (RGCs) is a key pathological process in TON, yet mechanisms …

Consumption of hydrogen water reduces paraquat‐induced acute lung injury in rats

S Liu, K Liu, Q Sun, W Liu, W Xu… - BioMed Research …, 2011 - Wiley Online Library
Exposure to paraquat leads to acute lung injury and oxidative stress is widely accepted as a
contributor to paraquat‐induced acute lung injury. Recent studies have reported that …