Fibrosis and cancer: Shared features and mechanisms suggest common targeted therapeutic approaches

L Landolt, GC Spagnoli, A Hertig… - Nephrology Dialysis …, 2022 - academic.oup.com
Epidemiological studies support a strong link between organ fibrosis and epithelial cancers.
Moreover, clinical and experimental investigations consistently indicate that these diseases …

Deciphering urogenital cancers through proteomic biomarkers: a systematic review and meta-analysis

AA Khan, N Al-Mahrouqi, A Al-Yahyaee, H Al-Sayegh… - Cancers, 2023 - mdpi.com
Simple Summary Urogenital cancers (prostate, bladder, kidney) have significant global
health impacts. Proteomic biomarkers are emerging tools that aim to improve early detection …

Connecting histopathology imaging and proteomics in kidney cancer through machine learning

F Azuaje, SY Kim, D Perez Hernandez… - Journal of clinical …, 2019 - mdpi.com
Proteomics data encode molecular features of diagnostic value and accurately reflect key
underlying biological mechanisms in cancers. Histopathology imaging is a well-established …

Massive proteogenomic reanalysis of publicly available proteomic datasets of human tissues in search for protein recoding via adenosine-to-inosine RNA editing

LI Levitsky, MV Ivanov, AO Goncharov… - Journal of Proteome …, 2023 - ACS Publications
The proteogenomic search pipeline developed in this work has been applied for reanalysis
of 40 publicly available shotgun proteomic datasets from various human tissues comprising …

Prognostic value of Talin-1 in renal cell carcinoma and its association with B7-H3

L Saeednejad Zanjani, S Vafaei… - Cancer …, 2022 - content.iospress.com
METHODS: Talin-1 protein was demonstrated as a potential prognostic marker in renal cell
carcinoma (RCC) using bioinformatics analysis. We, therefore, examined the protein …

Quadriceps strength and mortality in older patients with heart failure

T Nakamura, K Kamiya, N Hamazaki… - Canadian Journal of …, 2021 - Elsevier
Background This study was performed to test the hypothesis that low quadriceps isometric
strength (QIS) is associated with greater risk of mortality and has the additive prognostic …

Proteomic approaches for characterizing renal cell carcinoma

DJ Clark, H Zhang - Clinical Proteomics, 2020 - Springer
Renal cell carcinoma is among the top 15 most commonly diagnosed cancers worldwide,
comprising multiple sub-histologies with distinct genomic, proteomic, and clinicopathological …

[HTML][HTML] Quantitative proteomic analysis reveals sophisticated metabolic alteration and identifies FMNL1 as a prognostic marker in clear cell renal cell carcinoma

G Ma, Z Wang, J Liu, S Fu, L Zhang, D Zheng… - Journal of …, 2021 - ncbi.nlm.nih.gov
Purpose: In this study, we have undertaken the whole proteomic analysis and got a better
understanding of biological processes involved in the development and progression of …

Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma

R Riscal, SM Gardner, NJ Coffey, M Carens… - Cancer Research, 2024 - AACR
Clear cell renal cell carcinoma (ccRCC) incidence has risen steadily over the last decade.
Elevated lipid uptake and storage is required for ccRCC cell viability. As stored cholesterol is …

Optimal cutoff values for physical function tests in elderly patients with heart failure

K Aida, K Kamiya, N Hamazaki, K Nozaki, T Ichikawa… - Scientific Reports, 2022 - nature.com
Six-minute walk distance (6MWD) of 300 and 400 m are important targets of functional
capacity. The present study was performed to determine cutoff values of physical function …