Amyotrophic lateral sclerosis: moving towards a new classification system

A Al-Chalabi, O Hardiman, MC Kiernan, A Chiò… - The Lancet …, 2016 - thelancet.com
Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that
primarily affects upper and lower motor neurons, but also frontotemporal and other regions …

Neuropathology of amyotrophic lateral sclerosis and its variants

S Saberi, JE Stauffer, DJ Schulte… - Neurologic …, 2015 - neurologic.theclinics.com
The first case reports of amyotrophic lateral sclerosis (ALS) date back to Charles Bell in
1824. 1 Although a variety of other clinical descriptions followed throughout the 1850s, 2–4 …

Copy Number Variations in the Survival Motor Neuron Genes: Implications for Spinal Muscular Atrophy and Other Neurodegenerative Diseases

MER Butchbach - Frontiers in molecular biosciences, 2016 - frontiersin.org
Proximal spinal muscular atrophy (SMA), a leading genetic cause of infant death worldwide,
is an early-onset, autosomal recessive neurodegenerative disease characterized by the loss …

Amyotrophic lateral sclerosis: update on clinical management

SP Norris, MFN Likanje… - Current opinion in …, 2020 - journals.lww.com
ALS is a progressive neurodegenerative disease that causes degeneration of the motor
neurons which leads to paralysis and respiratory failure. Despite the lack of a cure …

Patterns of weakness, classification of motor neuron disease & clinical diagnosis of sporadic ALS

JM Statland, RJ Barohn, AL McVey, J Katz… - Neurologic …, 2015 - pmc.ncbi.nlm.nih.gov
When approaching the patient with suspected motor neuron disease (MND) the pattern of
weakness on exam helps distinguish MND from other diseases of peripheral nerves, the …

Current state and future directions in the diagnosis of amyotrophic lateral sclerosis

M Vidovic, LH Müschen, S Brakemeier, G Machetanz… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …

A systematic review of genotype–phenotype correlation across cohorts having causal mutations of different genes in ALS

O Connolly, L Le Gall, G McCluskey… - Journal of Personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis is a rare and fatal neurodegenerative disease characterised by
progressive deterioration of upper and lower motor neurons that eventually culminates in …

Plant-derived nootropics and human cognition: A systematic review

C Lorca, M Mulet, C Arévalo-Caro… - Critical Reviews in …, 2023 - Taylor & Francis
Substances with modulatory capabilities on certain aspects of human cognition have been
revered as nootropics from the dawn of time. The plant kingdom provides most of the …

Charcot-Marie-Tooth disease and other hereditary neuropathies

CJ Klein - CONTINUUM: Lifelong Learning in Neurology, 2020 - journals.lww.com
PURPOSE OF REVIEW This article provides an overview of Charcot-Marie-Tooth disease
(CMT) and other inherited neuropathies. These disorders encompass a broad spectrum with …

Frontotemporal pathology in motor neuron disease phenotypes: Insights from neuroimaging

MC McKenna, P Corcia, P Couratier, WF Siah… - Frontiers in …, 2021 - frontiersin.org
Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …