We review various mathematical and computational techniques for drug discovery
exemplifying some recent works pertinent to group theory of nested structures of relevance …

Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin.
In recent years, diabetes has become one of the rapidly growing chronic diseases, and it …

Abstract The Suzuki-Miyaura coupling is a widely used CC bond forming reaction.
Numerous mechanistic studies have enabled the use of low catalyst loadings and broad …

A series of arylalkylidene derivatives of 1, 3-thiazolidin-4-one (1–20) were synthesized and
tested for their antiviral activity against chikungunya virus (LR2006_OPY1) in Vero cell …

The structure–activity relationships and hit-to-lead optimization of dual Top1–TDP1
inhibitors in the indenoisoquinoline drug class were investigated. A series of nitrated 7-, 8-, 9 …

Poly (adenosine 5′-diphosphate-ribose) polymerase (PARP) inhibitors are a class of
anticancer drugs that block the catalytic activity of PARP proteins. Optimization of our lead …

Hepatitis C virus (HCV) mortality and morbidity is a world health misery with an approximate
130–150 million chronically HCV tainted and suffering individuals and it initiate critical liver …

About 130–150 million people worldwide are chronically infected with the hepatitis C virus
(HCV), and this infection can lead to serious liver problems such as cirrhosis, hepatocellular …

After the clinical use of epalrestat that contains a rhodanine ring, in type II diabetes mellitus
and diabetic complications, rhodanin-based compounds have become an important class of …

Background Some isoquinoline alkaloids from Macleaya cordata (Willd). R. Br.(Bo Luo Hui)
exhibited antibacterial, antiparasitic, antitumor, and analgesic effects. The targets of these …