In this issue of Structure, Holmes et al.(2005) describe elements of an innate defense
mechanism that provides mammals a means to restrict bacterial growth. The host protein …

Adverse metabolic effects, such as diabetes mellitus, lipid abnormalities and weight gain,
have increasingly been recognised with the use of the newer, so-called atypical …

OBJECTIVE: The association of hyperglycemia and hypercholesterolemia with use of
atypical antipsychotics has been documented in case reports and uncontrolled studies. The …

PURPOSE: Clozapine is a potent antipsychotic agent that has been marketed since 1990.
Several published reports of diabetes mellitus occurring with clozapine therapy have …

Clozapine (Clozaril®) is a novel and unique prototype atypical, tricyclic, dibenzodiazepine-
derivative, antipsychotic agent. It has been proven effective and significantly superior to …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Case reports and small retrospective studies suggest that atypical antipsychotic agents may
be associated with new-onset Type II diabetes mellitus (DM) or diabetic ketoacidosis (DKA); …

The available literature suggests that patients with schizophrenia are at risk for diabetes
mellitus and taking antipsychotic medication further increases the chance of developing non …

As a class, the atypical antipsychotics are the first line treatment choice for the
psychopharmacologic management of psychotic disorders. Emerging evidence currently …

The liver is the organ by which the majority of substances are metabolized, including
psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease …