T and B cell repertoires are collections of lymphocytes, each characterized by its antigen-
specific receptor. We review here classical technologies and analysis strategies developed …

With lymphoid tissue anatomy different than mammals, and diverse adaptations to all
aquatic environments, fish constitute a fascinating group of vertebrate to study the biology of …

Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the
response of a child with refractory bone marrow metastatic rhabdomyosarcoma to …

Gene editing using engineered nucleases frequently produces unintended genetic lesions
in hematopoietic stem cells (HSCs). Gene-edited HSC cultures thus contain heterogeneous …

Somatic assembly of T cell receptor and B cell receptor (BCR) genes produces a vast
diversity of lymphocyte antigen recognition capacity. The advent of efficient high-throughput …

Clones are the fundamental building blocks of immune repertoires. The number of different
clones relates to the diversity of the repertoire, whereas their size and sequence diversity …

Accurate characterization of the repertoire of the T-cell receptor (TCR) alpha and beta
chains is critical to understanding adaptive immunity. Such characterization has many …

Upon infection, B-lymphocytes expressing antibodies specific for the intruding pathogen
develop clonal responses triggered by pathogen recognition via the B-cell receptor. The …

The world is facing a pandemic of Corona Virus Disease 2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Adaptive immune …

Rasmussen encephalitis (RE) is a rare paediatric epilepsy with uni-hemispheric
inflammation and progressive neurological deficits. To elucidate RE immunopathology, we …