The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO2) nano-platform is
developed for not only tumor microenvironment (TME)-specific imaging and on-demand …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …