In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

The DNA-dependent protein kinase (DNA-PK) plays an instrumental role in the overall
survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related …

Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

Purpose The aim of this work is to review the published studies on radiation resistance
mechanisms and molecular markers involved in different tumors. The revision has been …

The DNA-PK holoenzyme is a fundamental element of the DNA damage response
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …

Ionizing radiation (IR) is a form of high energy. It poses a serious threat to organisms, but
radiotherapy is a key therapeutic strategy for various cancers. It is significant to reduce …

Non-coding RNA (ncRNA) has recently emerged as a vital component of the DNA damage
response (DDR), which was previously believed to be solely regulated by proteins. Many …

It is becoming clear that the DNA damage response orchestrates an appropriate response to
a given level of DNA damage, whether that is cell cycle arrest and repair, senescence or …