C Grinan-Ferre, A Bellver-Sanchis, V Izquierdo… - Ageing research …, 2021 - Elsevier
While the elderly segment of the population continues growing in importance, neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …
S Pal, JK Tyler - Science advances, 2016 - science.org
Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells …
The process of aging results in a host of changes at the cellular and molecular levels, which include senescence, telomere shortening, and changes in gene expression. Epigenetic …
AE Kane, DA Sinclair - Critical reviews in biochemistry and …, 2019 - Taylor & Francis
The aging process results in significant epigenetic changes at all levels of chromatin and DNA organization. These include reduced global heterochromatin, nucleosome remodeling …
YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High- throughput technologies enable omics studies interrogating thousands to millions of makers …
The increased prevalence and severity of periodontal disease have long been associated with aging, such that this oral condition affects the majority of the adult population over 50 …
M Zampieri, F Ciccarone, R Calabrese… - Mechanisms of ageing …, 2015 - Elsevier
A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …
CJ Marsit - Journal of Experimental Biology, 2015 - journals.biologists.com
Environmental toxicants can alter epigenetic regulatory features such as DNA methylation and microRNA expression. As the sensitivity of epigenomic regulatory features may be …
Background The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood samples, while …