Perspectives on primary blast injury of the brain: translational insights into non-inertial low-intensity blast injury

HR Siedhoff, S Chen, H Song, J Cui, I Cernak… - Frontiers in …, 2022 - frontiersin.org
Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild”
and frequently caused by non-impact blast exposures. Experimental models were …

Potential health and performance effects of high-level and low-level blast: a scoping review of two decades of research

JN Belding, RM Englert, S Fitzmaurice… - Frontiers in …, 2021 - frontiersin.org
Although blast exposure has been recognized as a significant source of morbidity and
mortality in military populations, our understanding of the effects of blast exposure …

Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice

C Li, S Chen, HR Siedhoff, DA Grant, P Liu… - Acta Neuropathologica …, 2023 - Springer
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health
problem affecting military service members and veterans. Our previous reports using a …

Mitochondrial dysfunction after repeated mild blast traumatic brain injury is attenuated by a mild mitochondrial uncoupling prodrug

WB Hubbard, HJ Vekaria, GV Velmurugan… - Journal of …, 2023 - liebertpub.com
Mild traumatic brain injury (mTBI) results in impairment of brain metabolism, which is
propagated by mitochondrial dysfunction in the brain. Mitochondrial dysfunction has been …

Traumatic brain injury recapitulates developmental changes of axons

H Song, C Chen, B Kelley, A Tomasevich, H Lee… - Progress in …, 2022 - Elsevier
During development, half of brain white matter axons are maintained for growth, while the
remainder undergo developmental axon degeneration. After traumatic brain injury (TBI) …

Brain-related proteins as serum biomarkers of acute, subconcussive blast overpressure exposure: a cohort study of military personnel

AM Boutte, B Thangavelu, CR LaValle, J Nemes… - PLoS one, 2019 - journals.plos.org
Repeated exposure to blast overpressure remains a major cause of adverse health for
military personnel who, as a consequence, are at a higher risk for neurodegenerative …

Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects

F Kobeissy, M Goli, H Yadikar, Z Shakkour… - Frontiers in …, 2023 - frontiersin.org
Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has
garnered significant attention in the context of neurotrauma research. Neuroproteomics …

Roadmap for advancing pre-clinical science in traumatic brain injury

DH Smith, PM Kochanek, S Rosi, R Meyer… - Journal of …, 2021 - liebertpub.com
Pre-clinical models of disease have long played important roles in the advancement of new
treatments. However, in traumatic brain injury (TBI), despite the availability of numerous …

Shock wave physics as related to primary non-impact blast-induced traumatic brain injury

B Rutter, H Song, RG DePalma, G Hubler… - Military …, 2021 - academic.oup.com
Introduction Blast overpressure exposure, an important cause of traumatic brain injury (TBI),
may occur during combat or military training. TBI, most commonly mild TBI, is considered a …

Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins …

S Chen, HR Siedhoff, H Zhang, P Liu… - Neurobiology of …, 2022 - Elsevier
Neurocognitive consequences of blast-induced traumatic brain injury (bTBI) pose significant
concerns for military service members and veterans with the majority of “invisible injury.” …