Background Cancer, the second leading cause of death worldwide following cardiovascular
diseases, presents a formidable challenge in clinical settings due to the extensive toxic side …

Steroidal saponins with diverse bioactivities have gained considerable attention. The genus
Trillium, a group of perennial flowering plants, is a prominent source of these compounds …

Dysregulation of the Hippo signaling pathway seen in many types of cancer is usually
associated with a poor prognosis. Paris saponin VII (PSVII) is a steroid saponin isolated from …

Introduction Polyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory,
analgesic, antibacterial, and antiviral properties. However, the current production of …

Paris polyphylla is an important traditional medicinal plant of the Himalayan region. It is
extensively used for the production of natural steroidal saponins and flavonoids. Although s …

Cancer is claimed as a prevalent cause of mortality throughout the world. Conventional
chemotherapy plays a pivotal role in the treatment of cancers, but multidrug resistance has …

Background Leukemia accounts for a large number of deaths, worldwide, every year.
Treating this ailment is always a challenging job. Recently, oncogenic miRNA leading to …

Background: Trillium tschonoskii Maxim (TTM) exerts antitumor effects on a variety of tumour
cells. However, the antitumor mechanism of Diosgenin glucoside (DG) extracted from TTM is …