Autoimmune effector mechanisms associated with a defective immunosuppressive axis in immune thrombocytopenia (ITP)

Q Li, G Marcoux, Y Hu, J Rebetz, L Guo, E Semple… - Autoimmunity …, 2024 - Elsevier
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated
thrombocytopenia and variable phenotype as some patients suffer no bleeding whilst others …

Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy

M Yan, Z Wang, Z Qiu, Y Cui, Q Xiang - Biomarker Research, 2024 - Springer
Platelets are essential for blood clotting and maintaining normal hemostasis. In pathological
conditions, platelets are increasingly recognized as crucial regulatory factors in various …

[HTML][HTML] Human cytochrome C natural variants: Studying the membrane binding properties of G41S and Y48H by fluorescence energy transfer and molecular …

A Muroni, V Minicozzi, MC Piro, F Sinibaldi… - International Journal of …, 2024 - Elsevier
Cytochrome C (cyt C), the protein involved in oxidative phosphorylation, plays several other
crucial roles necessary for both cell life and death. Studying natural variants of cyt C offers …

[HTML][HTML] Navigating Primary Immune Thrombocytopenia During Pregnancy With Management Strategies and Considerations: A Comprehensive Review

SM Dahiphale, D Dewani, M Agrawal, JM Dahiphale… - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a
reduction in platelet count due to autoantibody-mediated platelet destruction. ITP presents …

[HTML][HTML] The Many Faces of Immune Thrombocytopenia: Mechanisms, Therapies, and Clinical Challenges in Oncological Patients

M Kos, P Tomaka, P Mertowska… - Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
The pathogenesis of immune thrombocytopenia (ITP) is complex and involves the
dysregulation of immune cells, such as T and B lymphocytes, and several cytokines that …

Frequency of CD40‐1C>T polymorphism (rs1883832) and association with response to treatment in children with primary immune thrombocytopenia

HA Ahmed, E Abdelkreem, EO Hamed… - Pediatric Blood & …, 2024 - Wiley Online Library
Objectives: To investigate whether (cluster of differentiation) CD40‐1C> T (rs1883832)
contributes to predisposition and treatment response of primary immune thrombocytopenia …

The Incidence and Characteristics of Thrombosis in Patients with Immune thrombocytopenia: A Retrospective Cohort Study

P Zhang, Y Cai, F Ge, Z Zhu, K Sun - International Journal of …, 2024 - Taylor & Francis
Introduction This study aims to investigate the incidence, clinical characteristics, and
prognosis of thrombosis in Chinese patients with immune thrombocytopenia (ITP). Methods …

Role of Azathioprine in the Management of ITP in the TPO-RA Era: A Single Centre Retrospective Study

A Le-Nguyen, S Mortuza… - Blood Vessels, Thrombosis …, 2024 - ashpublications.org
Immune thrombocytopenia (ITP) is an autoimmune disease associated with low platelets
and risk of bleeding. Standard-of-care treatment now includes the novel thrombopoietin …

[HTML][HTML] Clinical efficacy of two different doses of rituximab as a treatment option in adult patients with chronic immune thrombocytopenia

DG El-Saied, AM Dwidar… - The Egyptian Journal of …, 2024 - ejim.springeropen.com
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with a high incidence
of chronicity among adults. Rituximab is recommended as a treatment option for chronic ITP …

Perioperatives Management bei Gerinnungsstörungen in der Ophthalmochirurgie

C Sucker, O Zeitz, N Feltgen - Klinische Monatsblätter für …, 2024 - thieme-connect.com
Disorders of blood coagulation can lead to manifest spontaneous bleeding and an
increased risk of bleeding during surgical procedures and interventions …