This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Butyric acid (BA) is a short-chain fatty acid (SCFA) produced by gut bacteria in the colon. We
hypothesized that colon-derived BA may affect hemodynamics. Arterial blood pressure (BP) …

Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

In humans, the TRP superfamily of cation channels includes 27 related molecules that
respond to a remarkable variety of chemical and physical stimuli. While physiological roles …

Abstract Calcium (Ca 2+) plays a central role in excitation, contraction, transcription, and
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …

Key points The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves
are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in …

In this article, we propose that differences in COVID-19 morbidity may be associated with
transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 …