Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …

Abstract We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-
genome sequencing (WGS) individuals and 5,841 high-density genotyping individuals, and …

The prevalence and clinical characteristics of depressive disorders differ between women
and men; however, the genetic contribution to sex differences in depressive disorders has …

Widely used genotype imputation methods are based on the Li and Stephens model, which
assumes that new haplotypes can be represented by modifying existing haplotypes in a …

Limited whole genome sequencing (WGS) studies in Asian populations result in a lack of
representative reference panels, thus hindering the discovery of ancestry-specific variants …

Natural selection signatures across Japanese subpopulations are under-explored. Here we
conducted genome-wide selection scans with 622,926 single nucleotide polymorphisms for …

Dear Editor, The genotype imputation is an efficient and pivotal approach to estimate the
unobserved genotypes in the genomic data from the single nucleotide polymorphism (SNP) …

Imputation is a method that supplies missing information about genetic variants that could
not be directly genotyped with DNA microarrays or low-coverage sequencing. Imputation …

Lung function reflects the ability of the respiratory system and is utilized for the assessment
of respiratory diseases. Because type 2 airway inflammation influences lung function …

We present an in-depth single-cell atlas of in vitro multiculture systems on human primary
airway epithelium derived from normal and diseased lungs of 27 individual donors. Our …