Identification and Application of Streptomyces rapamycinicus CQUSh011 against Potato Late Blight

X Luo, T Tian, X Tan, B Hu, P Li, S Feng… - Journal of Agricultural …, 2024 - ACS Publications
Using chemical fungicides is the main strategy for controlling potato late blight (PLB), a
devastating pre-and postharvest disease caused by Phytophthora infestans, resulting in …

Engineered CRISPR-Cas9 for Streptomyces sp. genome editing to improve specialized metabolite production

DG Kim, B Gu, Y Cha, J Ha, Y Lee, G Kim… - Nature …, 2025 - nature.com
The CRISPR-Cas9 system has frequently been used for genome editing in Streptomyces;
however, cytotoxicity, caused by off-target cleavage, limits its application. In this study, we …

Quorum sensing‐based metabolic engineering of the precursor supply in Streptomyces coelicolor to improve heterologous production of neoaureothin

DK Kim, B Gu, DG Kim, MK Oh - Biotechnology and …, 2023 - Wiley Online Library
Streptomyces are important industrial bacteria that produce pharmaceutically valuable
polyketides. However, mass production on an industrial scale is limited by low productivity …

Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis

D Xu, Y Wang, H Li, B Wang, L Chai, L Feng… - Microbial Cell …, 2024 - Springer
Rapamycin is an important natural macrolide antibiotic with antifungal, immunosuppressive
and antitumor activities produced by Streptomyces rapamycinicus. However, their …

Oxytetracycline hyper-production through targeted genome reduction of Streptomyces rimosus

A Pšeničnik, L Slemc, M Avbelj, M Tome, M Šala… - Msystems, 2024 - Am Soc Microbiol
Most biosynthetic gene clusters (BGC) encoding the synthesis of important microbial
secondary metabolites, such as antibiotics, are either silent or poorly expressed; therefore …

Extracellular Biosynthesis Silver Nanoparticles Using Streptomyces spp. and Evaluating Its Effects Against Important Tomato Pathogens and Cancer Cells

MS Nejad, S Tarighi, P Taheri, M Darroudi - BioNanoScience, 2024 - Springer
Tomato (Solanum lycopersicum L.) holds significant importance as a primary vegetable crop
globally. In this research, the extracellular green-synthesis of silver nanoparticles was …

Oxytetracycline hyper-production through targeted genome reduction of Streptomyces rimosus

H Petković, A Pšeničnik, L Slemc, M Avbelj, M Tome… - 2023 - researchsquare.com
Most of the biosynthetic gene clusters (BGC) encoding the biosynthesis of important
microbial secondary metabolites, such as antibiotics, are either silent or poorly expressed; …

[HTML][HTML] Novel Drug Development for Treatment of COVID-19 by In Silico Analysis: Identification of SARS-Cov-2 Inhibiting Streptomyces Compounds

J Kumar, P Gholap, TG Pillai - Journal of Cellular Signaling, 2023 - scientificarchives.com
In accordance with the present epidemiological paradigm, viral mutations of the virus are on
the rise, and their natural effects are being selected for at a higher rate than normal …

[图书][B] Antibiotics and Secondary Metabolites Analysis SHell (antiSMASH) as a Tool to Detect Putative Novel Antibiotics

R Snape - 2023 - search.proquest.com
Abstract In the Hudson Lab, which is focused on discovering new antibiotics, bacteria
samples are taken from the environment and cultured in large quantities. Then they are …