The Golgi Complex is the central hub in the endomembrane system and serves not only as a
biosynthetic and processing center but also as a trafficking and sorting station for …

Background Neuronal death due to over-oxidative stress responses defines the pathology of
cerebral ischemic/reperfusion (I/R) insult. Ferroptosis is a form of oxidative cell death that is …

The anti-cancer mechanism of High-dose Vitamin C (HDVC) is mainly to participate in the
Fenton reaction, hydroxylation reaction, and epigenetic modification, which leads to the …

Exosome-encapsulated microRNAs (miRNAs) have been identified as potential cancer
biomarkers and pro-tumorigenic mediators for several cancers. However, the miRNA …

大剂量维生素C (HVC) 治疗是一种相对安全和廉价的肿瘤治疗方法, 能够通过促氧化应激,
表观遗传修饰, 抑制缺氧诱导因子(HIF-α) 和免疫调控等途径产生抗肿瘤作用, 然而, HVC …

One of abundant DNA lesions induced by reactive oxygen species is 8-oxoguanine (8-
oxoG), which compromises genetic instability. 8-oxoG is recognized by the DNA repair …

Cholangiocarcinoma (CCA) is a group of malignancies emerging in the biliary tree and is
associated with a poor patient prognosis. Although the anatomical location is the only …

Isoprenylation is an important post-transcriptional modification of small GTPases required for
their activation and function. Isoprenoids, including farnesyl pyrophosphate (FPP) and …

RAS genes encode signaling proteins, which, in mammalian cells, act as molecular switches
regulating critical cellular processes as proliferation, growth, differentiation, survival, motility …

Background: Vitamin K derivatives have an important role in bone formation and blood
clotting. Vitamin K 2 [menaquinone-4 (MK-4)] is used for the treatment and prevention of …