In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …

Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …

Lysosomal acid lipase (LAL) is the sole enzyme known to degrade neutral lipids in the
lysosome. Mutations in the LAL-encoding LIPA gene lead to rare lysosomal lipid storage …

Oxidative stress induced by chemotherapeutic agents causes hepatotoxicity. 5-Fluorouracil
(5-FU) has been found to have a variety of side effects, but its toxic effect on the liver and the …

Omega-3 fatty acids, including alpha-linolenic acids (ALA), eicosapentaenoic acid (EPA),
and docosahexaenoic acid (DHA), have shown major health benefits, but the human body's …

Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events.
Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence …

Age-related macular degeneration (AMD), the leading cause of irreversible blindness in the
elderly, is primarily characterized by the degeneration of the retinal pigment epithelium …

Background The failure of proper recognition of the intricate nature of pathophysiology in
colorectal cancer (CRC) has a substantial effect on the progress of developing novel …

We performed liquid chromatography tandem mass spectrometry analysis with the targeted
metabolomic kit Biocrates MxP Quant 500, in human brain cortex (Brodmann area 9) and …