Excitable Astrocytes: Ca2+- and cAMP-Regulated Exocytosis
During neural activity, neurotransmitters released at synapses reach neighbouring cells,
such as astrocytes. These get excited via numerous mechanisms, including the G protein …
such as astrocytes. These get excited via numerous mechanisms, including the G protein …
Loose excitation–secretion coupling in astrocytes
Astrocytes play an important housekeeping role in the central nervous system. Additionally,
as secretory cells, they actively participate in cell‐to‐cell communication, which can be …
as secretory cells, they actively participate in cell‐to‐cell communication, which can be …
Nano‐analysis Reveals High Fraction of Serotonin Release during Exocytosis from a Gut Epithelium Model Cell
Electrochemical methods were used to explore the exocytotic nature of serotonin (5‐HT)
release in human carcinoid BON cells, an in vitro human enterochromaffin cell model, to …
release in human carcinoid BON cells, an in vitro human enterochromaffin cell model, to …
Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the
extracellular space, through which small transmitter molecules such as ATP can exit. Co …
extracellular space, through which small transmitter molecules such as ATP can exit. Co …
Single‐Vesicle Electrochemistry Following Repetitive Stimulation Reveals a Mechanism for Plasticity Changes with Iron Deficiency
Deficiency of iron, the most abundant transition metal in the brain and important for neuronal
activity, is known to affect synaptic plasticity, causing learning and memory deficits. How iron …
activity, is known to affect synaptic plasticity, causing learning and memory deficits. How iron …
Astrocyte specific remodeling of plasmalemmal cholesterol composition by ketamine indicates a new mechanism of antidepressant action
E Lasič, M Lisjak, A Horvat, M Božić, A Šakanović… - Scientific reports, 2019 - nature.com
Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although
the underlying mechanism (s) remain unknown. Using FRET-based nanosensors we found …
the underlying mechanism (s) remain unknown. Using FRET-based nanosensors we found …
Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability
L Zelkas, R Raghupathi, AL Lumsden, AM Martin… - Nutrition & …, 2015 - Springer
Background Enteroendocrine cells collectively constitute our largest endocrine tissue, with
serotonin (5-HT) secreting enterochromaffin (EC) cells being the largest component (~ 50%) …
serotonin (5-HT) secreting enterochromaffin (EC) cells being the largest component (~ 50%) …
Gliocrine system: Astroglia as secretory cells of the CNS
Astrocytes are secretory cells, actively participating in cell-to-cell communication in the
central nervous system (CNS). They sense signaling molecules in the extracellular space …
central nervous system (CNS). They sense signaling molecules in the extracellular space …
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells
The adrenomedullary chromaffin cell transduces chemical messages into outputs that
regulate end organ function throughout the periphery. At least two important …
regulate end organ function throughout the periphery. At least two important …
The synaptotagmin-1 C2B domain is a key regulator in the stabilization of the fusion pore
Fusion pores serve as an effective mechanism to connect intracellular organelles and
release vesicle contents during exocytosis. A complex lipid rearrangement takes place as …
release vesicle contents during exocytosis. A complex lipid rearrangement takes place as …