Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

In this review we focus on the idea of establishing connections between the mechanical
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …

SYBR Gold is a commonly used and particularly bright fluorescent DNA stain, however, its
chemical structure is unknown and its binding mode to DNA remains controversial. Here, we …

Mechanical properties of single double-stranded DNA (dsDNA) in the presence of different
binding ligands were analyzed in optical-tweezers experiments with subpiconewton force …

Interfacial interactions between immobilized DNA probes and DNA-specific sequence
binding drugs were investigated using impedance spectroscopy toward the development of …

The combination of biology and nanotechnology has led to a new generation of
nanodevices that make it possible to characterize the chemical, mechanical, and other …

DNA-binding small molecules are widespread in the cell and heavily used in biological
applications. Here, we use magnetic tweezers, which control the force and torque applied to …

Here we explore DNA binding by a family of ruthenium (II) polypyridyl complexes using an
atomic force microscope (AFM) and optical tweezers. We demonstrate using AFM that Ru …

We have performed single-molecule stretching and dynamic light-scattering (DLS)
experiments to characterize the interaction between the DNA molecule and the fluorescent …

When a single DNA molecule is stretched beyond its normal contour length, a force-induced
melting transition is observed. Ethidium binding increases the DNA contour length …