Clinical significance of FBXW7 loss of function in human cancers
J Fan, M Bellon, M Ju, L Zhao, M Wei, L Fu, C Nicot - Molecular cancer, 2022 - Springer
Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7)(also referred to as FBW7 or
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …
HIF‐1 at the crossroads of hypoxia, inflammation, and cancer
K Balamurugan - International journal of cancer, 2016 - Wiley Online Library
The complex cross‐talk of intricate intercellular signaling networks between the tumor and
stromal cells promotes cancer progression. Hypoxia is one of the most common conditions …
stromal cells promotes cancer progression. Hypoxia is one of the most common conditions …
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Astrocytes become reactive in response to insults to the central nervous system by adopting
context-specific cellular signatures and outputs, but a systematic understanding of the …
context-specific cellular signatures and outputs, but a systematic understanding of the …
FBXW7 in cancer: what has been unraveled thus far?
The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the
crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …
crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …
Recent insight into the role of FBXW7 as a tumor suppressor
K Yumimoto, KI Nakayama - Seminars in cancer biology, 2020 - Elsevier
FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation
Colorectal cancer (CRC), the second leading cause of cancer-related deaths in the US, has
been treated with targeted therapies. However, the mechanisms of differential responses …
been treated with targeted therapies. However, the mechanisms of differential responses …
[HTML][HTML] Regulatory mechanism of HIF-1α and its role in liver diseases: a narrative review
Q Chu, X Gu, Q Zheng, H Zhu - Annals of Translational Medicine, 2022 - ncbi.nlm.nih.gov
Objective To summarize the structure, regulatory mechanism, and target genes of hypoxia-
inducible factor-1 alpha (HIF-1α) and to comprehensively expound its role in various chronic …
inducible factor-1 alpha (HIF-1α) and to comprehensively expound its role in various chronic …
Targeting the ubiquitin pathway for cancer treatment
J Liu, S Shaik, X Dai, Q Wu, X Zhou, Z Wang… - Biochimica et Biophysica …, 2015 - Elsevier
Proteasome-mediated degradation is a common mechanism by which cells renew their
intracellular proteins and maintain protein homeostasis. In this process, the E3 ubiquitin …
intracellular proteins and maintain protein homeostasis. In this process, the E3 ubiquitin …
An integrated view of cyclin E function and regulation
KT Siu, MR Rosner, AC Minella - Cell cycle, 2012 - Taylor & Francis
Cancers of diverse cell lineages express high levels of cyclin E, and in various studies,
cyclin E overexpression correlates with increased tumor aggression. One way that normal …
cyclin E overexpression correlates with increased tumor aggression. One way that normal …
[HTML][HTML] Tumor suppressor functions of FBW7 in cancer development and progression
Z Wang, H Inuzuka, J Zhong, L Wan, H Fukushima… - FEBS letters, 2012 - Elsevier
FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-
suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its …
suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its …