How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Modeling arterial pulse waves in healthy aging: a database for in silico evaluation of hemodynamics and pulse wave indexes

PH Charlton, J Mariscal Harana… - American Journal …, 2019 - journals.physiology.org
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It
is widely measured by both consumer and clinical devices. However, the physical …

[HTML][HTML] Age-related impairment of vascular structure and functions

X Xu, B Wang, C Ren, J Hu, DA Greenberg… - Aging and …, 2017 - ncbi.nlm.nih.gov
Among age-related diseases, cardiovascular and cerebrovascular diseases are major
causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age …

Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence

JC Wang, M Bennett - Circulation research, 2012 - Am Heart Assoc
Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

J Totoń-Żurańska, TP Mikolajczyk, B Saju… - Clinical …, 2024 - portlandpress.com
Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

P Lacolley, V Regnault, A Nicoletti, Z Li… - Cardiovascular …, 2012 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, continually
exposed to mechanical signals and biochemical components generated in the blood …

Anatomic assessment of sympathetic peri-arterial renal nerves in man

K Sakakura, E Ladich, Q Cheng, F Otsuka… - Journal of the American …, 2014 - jacc.org
Background: Although renal sympathetic denervation therapy has shown promising results
in patients with resistant hypertension, the human anatomy of peri-arterial renal nerves is …

[HTML][HTML] Vascular biology of ageing—Implications in hypertension

A Harvey, AC Montezano, RM Touyz - Journal of molecular and cellular …, 2015 - Elsevier
Ageing is associated with functional, structural and mechanical changes in arteries that
closely resemble the vascular alterations in hypertension. Characteristic features of large …

[HTML][HTML] Elastic fibers during aging and disease

A Heinz - Ageing research reviews, 2021 - Elsevier
Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a “set up” for vascular disease

EG Lakatta, D Levy - Circulation, 2003 - Am Heart Assoc
disease identified by the epidemiologists. If the variable is perceived as beneficial or
deleterious with respect to cardiovascular structure or function, those with extreme measures …