[HTML][HTML] The epigenetic hallmark of early-life α-hexabromocyclododecane exposure: From cerebellar 6-mA levels to locomotor performance in adulthood
C Holuka, C Morel, S Roth, Y Lamartinière… - Environment …, 2023 - Elsevier
There is a growing evidence that methylation at the N 6 position of adenine (6-mA), whose
modulation occurs primarily during development, would be a reliable epigenetic marker in …
modulation occurs primarily during development, would be a reliable epigenetic marker in …
[HTML][HTML] Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring …
O Myhre, KE Zimmer, AM Hudecova, KEA Hansen… - Chemosphere, 2021 - Elsevier
Male and female mice pups were exposed to a low and high dose of a human relevant
mixture of persistent organic pollutants (POPs) during pregnancy and lactation. Most …
mixture of persistent organic pollutants (POPs) during pregnancy and lactation. Most …
Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice
NE Kramer, CE Fillmore, EG Slane… - Toxicological …, 2024 - academic.oup.com
Brominated flame retardants (BFRs) reduce flammability in a wide range of products
including electronics, carpets, and paint, but leach into the environment to result in …
including electronics, carpets, and paint, but leach into the environment to result in …
Biomagnification of Hexabromocyclododecane (HBCD) in a coastal ecosystem near a large producer in China: Human exposure implication through food web transfer
Hexabromocyclododecane (HBCD) is a widely used brominated flame retardant which is
mainly produced in China. Many HBCD facilities are located at the coast and the released …
mainly produced in China. Many HBCD facilities are located at the coast and the released …
Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2. 5
M Wu, D Wu, C Wang, Z Guo, B Li, Z Zuo - Journal of Hazardous Materials, 2016 - Elsevier
Hexabromocyclododecane (HBCD) is one of the most widely used brominated flame
retardants. Although studies have reported that HBCD can cause a wide range of toxic …
retardants. Although studies have reported that HBCD can cause a wide range of toxic …
Short-term effects of a perinatal exposure to the HBCDD α-isomer in rats: Assessment of early motor and sensory development, spontaneous locomotor activity and …
N Maurice, JC Olry, R Cariou, G Dervilly-Pinel… - Neurotoxicology and …, 2015 - Elsevier
The present study investigated the developmental neurotoxicity of an early exposure to α-
HBCDD through the ingestion of contaminated hen's egg in pregnant and lactating Wistar …
HBCDD through the ingestion of contaminated hen's egg in pregnant and lactating Wistar …
Serum metabolomic profiles in neonatal mice following oral brominated flame retardant exposures to hexabromocyclododecane (HBCD) alpha, gamma, and …
DT Szabo, W Pathmasiri, S Sumner… - Environmental health …, 2017 - ehp.niehs.nih.gov
Background: Hexabromocyclododecane (HBCD) is a high production volume brominated
flame retardant added to building insulation foams, electronics, and textiles. HBCD is a …
flame retardant added to building insulation foams, electronics, and textiles. HBCD is a …
Integrated risk assessment of dietary exposure and body burden of three brominated flame retardants in childbearing-aged Chinese women and breastfeeding infants
X Zhao, L Zhang, B Lyu, J Li, Y Zhao, Y Wu… - Environmental Research, 2025 - Elsevier
Based on the third Chinese National Human Milk Survey (NHMS) conducted in 2016-2019,
three typical legacy brominated flame retardants (BFRs), namely decabromodiphenyl ether …
three typical legacy brominated flame retardants (BFRs), namely decabromodiphenyl ether …
The brominated flame retardant hexabromocyclododecane causes systemic changes in polyunsaturated fatty acid incorporation in mouse lipids
NE Kramer, J Siracusa, H Xu, LM Barnett… - Toxicological …, 2025 - academic.oup.com
Brominated flame retardants are used in many household products to reduce flammability,
but often leach into the surrounding environment over time. Hexabromocyclododecane …
but often leach into the surrounding environment over time. Hexabromocyclododecane …
Head-to-head study of developmental neurotoxicity and resultant phenotype in rats: α-hexabromocyclododecane versus valproic acid, a recognized model of …
C Morel, A Christophe, K Maguin-Gaté, J Paoli… - Toxics, 2022 - mdpi.com
Evidence is now growing that exposure to environmental pollutants during the critical early-
life period of brain development may contribute to the emergence of Autism Spectrum …
life period of brain development may contribute to the emergence of Autism Spectrum …