Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

DNA double-strand breaks (DSBs) are among the most deleterious forms of DNA lesions in
cells. Here we induced site-specific DSBs in yeast cells and monitored chromatin dynamics …

Chromosome pairing is an essential meiotic event that ensures faithful haploidization and
recombination of the genome. Pairing of homologous chromosomes is facilitated by …

Budding yeast, like other eukaryotes, carries its genetic information on chromosomes that
are sequestered from other cellular constituents by a double membrane, which forms the …

▪ Abstract Nucleation of microtubules by eukaryotic microtubule organizing centers (MTOCs)
is required for a variety of functions, including chromosome segregation during mitosis and …

Early observations of centrosomes, made a century ago, revealed a tiny dark structure
surrounded by a radial array of cytoplasmic fibers. We now know that the fibers are …