Although precision medicine has had a mixed impact on the clinical management of patients
with advanced-stage cancer overall, for NSCLC, and more specifically for lung …

MicroRNAs (miRNAs) are endogenously initiated, small non-coding RNAs and typically
regulate the expression of mRNAs in post transcriptional level either via translational …

Precision oncology is predicated upon the ability to detect specific actionable genomic
alterations and to monitor their adaptive evolution during treatment to counter resistance …

Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

We discuss the current status of liquid biopsy and its advantages and challenges with a
focus on pre-analytical sample handling, technologies and workflows. The potential of …

MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that regulate numerous
biological processes by targeting a broad set of messenger RNAs. Recently, miRNAs have …

Circulating cell-free DNA (cfDNA) is becoming an important clinical analyte for prenatal
testing, cancer diagnosis and cancer monitoring. The extraction stage is critical in ensuring …

Recently, many genome‐wide profiling studies provided insights into the molecular make‐
up of major cancer types. The deeper understanding of these genetic alterations and their …

In the last years, circulating miRNAs have emerged as a new class of promising cancer
biomarkers. Independent studies have shown the feasibility of using these small RNAs as …

Purpose: The purpose of this study was to directly compare mutation profiles in multiple
single circulating tumor cells (CTC) and cell-free DNA (cfDNA) isolated from the same blood …