Epigenetic dysregulation has long been recognized as a key factor contributing to
tumorigenesis and tumour maintenance that can influence all of the recognized hallmarks of …

Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Mycosis fungoides (MF) and Sézary syndrome (SS) comprise approximately 53% of
cutaneous lymphomas. Both MF and SS may clinically and histologically mimic benign skin …

DNA double-strand break (DSB) repair occurs within chromatin and can be modulated by
chromatin-modifying enzymes. Here we identify the related human histone deacetylases …

Purpose Epigenetic processes are implicated in cancer causation and progression. The
acetylation status of histones regulates access of transcription factors to DNA and influences …

Abnormal epigenetic control is a common early event in tumour progression, and aberrant
acetylation in particular has been implicated in tumourigenesis. One of the most promising …

Both mycosis fungoides (MF) and Sézary syndrome (SS) have a chronic, relapsing course,
with patients frequently undergoing multiple, consecutive therapies. Treatment is aimed at …

The generation of DNA lesions and the resulting activation of DNA damage response (DDR)
pathways are both affected by the chromatin status at the site of damaged DNA. In turn, DDR …

Histone deacetylases are known to play a central role in the regulation of several cellular
properties intimately interlinked with the development and progression of cancer …

Recognition and repair of damaged DNA occurs within the context of chromatin. The key
protein components of chromatin are histones, whose post‐translational modifications …