X Lan, X Han, Q Li, QW Yang, J Wang - Nature Reviews Neurology, 2017 - nature.com
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. Microglia are among the first non-neuronal cells on the scene during the …
H Zheng, C Chen, J Zhang, Z Hu - Cerebrovascular diseases, 2016 - karger.com
Background: Intracerebral hemorrhage (ICH) is a subtype of stroke with a severe high mortality and disability rate and accounts for about 10-15% of all strokes. The oppression …
Y Fu, J Hao, N Zhang, L Ren, N Sun, YJ Li… - JAMA …, 2014 - jamanetwork.com
Importance Pronounced inflammatory reactions occurring shortly after intracerebral hemorrhage (ICH) contribute to the formation and progression of perihematomal edema …
Abstract Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously expressed. S1P-S1PR signaling has been well characterized in immune trafficking and …
R Brunkhorst, R Vutukuri, W Pfeilschifter - Frontiers in cellular …, 2014 - frontiersin.org
Sphingolipids are a fascinating class of signaling molecules derived from the membrane lipid sphingomyelin. They show abundant expression in the brain. Complex sphingolipids …
The characterization of molecular pathways that modulate blood–brain barrier (BBB) function and integrity has been fueled by a growing body of literature implicating BBB …
T Bobinger, P Burkardt, HB Huttner… - Current …, 2018 - ingentaconnect.com
Background: Intracerebral hemorrhage (ICH) accounts for up to 15% of all strokes and is characterized by high rates of mortality and morbidity. The post-ICH brain injury can be …
S Pournajaf, L Dargahi, M Javan… - Frontiers in …, 2022 - frontiersin.org
Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully utilized in the management of multiple sclerosis. The active metabolite, fingolimod …