Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation
Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …
Modulators of microglial activation and polarization after intracerebral haemorrhage
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …
[HTML][HTML] Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets
C Tschoe, CD Bushnell, PW Duncan… - Journal of …, 2020 - ncbi.nlm.nih.gov
Spontaneous intracerebral hemorrhage (ICH) is a catastrophic illness causing significant
morbidity and mortality. Despite advances in surgical technique addressing primary brain …
morbidity and mortality. Despite advances in surgical technique addressing primary brain …
Mechanism and therapy of brain edema after intracerebral hemorrhage
H Zheng, C Chen, J Zhang, Z Hu - Cerebrovascular diseases, 2016 - karger.com
Background: Intracerebral hemorrhage (ICH) is a subtype of stroke with a severe high
mortality and disability rate and accounts for about 10-15% of all strokes. The oppression …
mortality and disability rate and accounts for about 10-15% of all strokes. The oppression …
Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study
Y Fu, J Hao, N Zhang, L Ren, N Sun, YJ Li… - JAMA …, 2014 - jamanetwork.com
Importance Pronounced inflammatory reactions occurring shortly after intracerebral
hemorrhage (ICH) contribute to the formation and progression of perihematomal edema …
hemorrhage (ICH) contribute to the formation and progression of perihematomal edema …
Sphingosine-1-phosphate (S1P) and S1P signaling pathway: therapeutic targets in autoimmunity and inflammation
HC Tsai, MH Han - Drugs, 2016 - Springer
Abstract Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously
expressed. S1P-S1PR signaling has been well characterized in immune trafficking and …
expressed. S1P-S1PR signaling has been well characterized in immune trafficking and …
Fingolimod for the treatment of neurological diseases—state of play and future perspectives
R Brunkhorst, R Vutukuri, W Pfeilschifter - Frontiers in cellular …, 2014 - frontiersin.org
Sphingolipids are a fascinating class of signaling molecules derived from the membrane
lipid sphingomyelin. They show abundant expression in the brain. Complex sphingolipids …
lipid sphingomyelin. They show abundant expression in the brain. Complex sphingolipids …
Sphingosine 1-phosphate signaling at the blood–brain barrier
The characterization of molecular pathways that modulate blood–brain barrier (BBB)
function and integrity has been fueled by a growing body of literature implicating BBB …
function and integrity has been fueled by a growing body of literature implicating BBB …
Programmed cell death after intracerebral hemorrhage
T Bobinger, P Burkardt, HB Huttner… - Current …, 2018 - ingentaconnect.com
Background: Intracerebral hemorrhage (ICH) accounts for up to 15% of all strokes and is
characterized by high rates of mortality and morbidity. The post-ICH brain injury can be …
characterized by high rates of mortality and morbidity. The post-ICH brain injury can be …
Molecular pharmacology and novel potential therapeutic applications of fingolimod
Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …