With the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells …

Abstract γδ T cells have several innate cell-like features that allow their early activation
following recognition of conserved stress-induced ligands. Here we review recent …

Antibody production is an important feature of the vertebrate immune system. Antibodies
neutralize and clear pathogens, thereby protecting against infectious diseases. Such …

A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …

Human γδ T cells are considered to play a vital role in protective immunity through cytokine
secretion and cytotoxic activity. We report that cells expressing the Vγ2Vδ2+–T cell receptor …

The investigation of γδ T cells has identified a rapid lymphoid stress-surveillance response
to microbial and nonmicrobial tissue perturbation. In addition to providing local protection …

T cell help for antibody production is a fundamental aspect of immune responses. Only
recently has a better understanding of the cellular and molecular mechanisms for T cell help …

The γδ T cell lineage in humans remains much of an enigma due to the low number of
defined antigens, the non-canonical ways in which these cells respond to their environment …

Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

In healthy adults, the major peripheral blood γδ T-cell subset expresses the Vγ9Vδ2 TCR
and displays pleiotropic features. Here we report that coculture of naive Vγ9Vδ2 T cells with …