Lung cancer screening with low-dose CT: what we have learned in two decades of ITALUNG and what is yet to be addressed

M Mascalchi, G Picozzi, D Puliti, S Diciotti, A Deliperi… - Diagnostics, 2023 - mdpi.com
The ITALUNG trial started in 2004 and compared lung cancer (LC) and other-causes
mortality in 55–69 years-aged smokers and ex-smokers who were randomized to four …

PET/MRI attenuation estimation in the lung: a review of past, present, and potential techniques

J Lillington, L Brusaferri, K Kläser, K Shmueli… - Medical …, 2020 - Wiley Online Library
Positron emission tomography/magnetic resonance imaging (PET/MRI) potentially offers
several advantages over positron emission tomography/computed tomography (PET/CT), for …

Towards large-scale case-finding: training and validation of residual networks for detection of chronic obstructive pulmonary disease using low-dose CT

LYW Tang, HO Coxson, S Lam, J Leipsic… - The Lancet Digital …, 2020 - thelancet.com
Background Chronic obstructive pulmonary disease (COPD) is underdiagnosed in the
community. Thoracic CT scans are widely used for diagnostic and screening purposes for …

In-vivo lung fibrosis staging in a bleomycin-mouse model: a new micro-CT guided densitometric approach

L Mecozzi, M Mambrini, F Ruscitti, E Ferrini… - Scientific reports, 2020 - nature.com
Although increasing used in the preclinical testing of new anti-fibrotic drugs, a thorough
validation of micro-computed tomography (CT) in pulmonary fibrosis models has not been …

Low-dose CT for lung cancer screening: Position paper from the Italian college of thoracic radiology

M Silva, G Picozzi, N Sverzellati, S Anglesio… - La radiologia …, 2022 - Springer
Smoking is the main risk factor for lung cancer (LC), which is the leading cause of cancer-
related death worldwide. Independent randomized controlled trials, governmental and inter …

Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

C McCarthy, E Lee, JP Bridges, A Sallese… - Nature …, 2018 - nature.com
Pulmonary alveolar proteinosis (PAP) is a syndrome of reduced GM-CSF-dependent,
macrophage-mediated surfactant clearance, dysfunctional foamy alveolar macrophages …

Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report

CCW Hsia, JHT Bates, B Driehuys, SB Fain… - Annals of the …, 2023 - atsjournals.org
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys

TA Aweda, SH Cheng, SC Lenhard, A Sepp… - European Journal of …, 2023 - Springer
Abstract Purpose Sotrovimab (VIR-7831), a human IgG1κ monoclonal antibody (mAb), binds
to a conserved epitope on the SARS-CoV-2 spike protein receptor binding domain (RBD) …

Computed tomography semi-automated lung volume quantification in SARS-CoV-2-related pneumonia

D Ippolito, M Ragusi, D Gandola, C Maino… - European …, 2021 - Springer
Objectives To evaluate a semi-automated segmentation and ventilated lung quantification
on chest computed tomography (CT) to assess lung involvement in patients affected by …

Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes

B Coiffard, S Riegler, MC Sklar, M Dres, S Vorona… - Critical Care, 2021 - Springer
Background Acute increases in muscle sonographic echodensity reflect muscle injury.
Diaphragm echodensity has not been measured in mechanically ventilated patients. We …