First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
43381412&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

2016-09-20 Assigned to AGIOS PHARMACEUTICALS, INC. reassignment AGIOS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

US7829694B2 - Treatment of neurodegenerative disease through intracranial delivery of siRNA
- Google Patents US7829694B2 - Treatment of neurodegenerative disease through intracranial …

C12N15/113—Non-coding nucleic acids modulating the expression of genes, eg antisense
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …

3,046,122 A 7, 1962 Oskar et al. 3,097,210 A* 7/1963 Bicking..................... 546,276.1
3,998,828 A 12/1976 Wiedermann 4,235,871 A 11/1980 Papahadjopoulos et al. 4,315,940 …

The present invention relates to a method of thera peutic or prophylactic treatment of a
mammalian CNS disorder by effecting local administration of an iRNA agent which is …

Disclosed herein are sequences, molecules and methods used to suppress the expression
of HD genes encoding for huntingtin protein in primates including Macaca mulatta and …

US9850277B2 - Therapeutically active compositions and their methods of use - Google Patents
US9850277B2 - Therapeutically active compositions and their methods of use - Google Patents …

3,514.462 A 5, 1970 Hester 4,978,669 A 12/1990 Barchas et al. 4,985,422 A 1/1991 North et
al. 5,013,733. A 5, 1991 Coates et al. 5,162.336 A 11/1992 Molino et al. 5,169,852 A …

Provided are aryl sulfonamide diarylurea derivative com pounds that are inhibitors of mutant
isocitrate dehydroge nase 1/2 (IDH 1/2), useful for treating cancer. Also provided are …