The challenges of primary biliary cholangitis: What is new and what needs to be done
BT Beretta-Piccoli, G Mieli-Vergani, D Vergani… - Journal of …, 2019 - Elsevier
Abstract Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …
Animal models of primary biliary cirrhosis
T Katsumi, K Tomita, PSC Leung, G Yang… - Clinical reviews in …, 2015 - Springer
Primary biliary cirrhosis (PBC) is characterized histologically by the presence of chronic non-
suppurative destructive cholangitis of the small interlobular bile duct, leading to chronic …
suppurative destructive cholangitis of the small interlobular bile duct, leading to chronic …
Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4+ T cells
ZB Zhao, FT Lu, HD Ma, YH Wang, W Yang… - Cellular & Molecular …, 2020 - nature.com
Liver-resident NK cells are distinct from conventional NK cells and play an important role in
the maintenance of liver homeostasis. How liver-resident NK cells participate in autoimmune …
the maintenance of liver homeostasis. How liver-resident NK cells participate in autoimmune …
Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption
A Abu-Romman, KK Scholand, S Pal-Ghosh, Z Yu… - The ocular …, 2023 - Elsevier
Purpose IL-2 promotes activation, clonal expansion, and deletion of T cells. IL-2 signals
through its heterotrimeric receptor (IL-2R) consisting of the CD25, CD122 and CD132 …
through its heterotrimeric receptor (IL-2R) consisting of the CD25, CD122 and CD132 …
Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis
Abstract CD4+ Foxp3+ regulatory T cells (Tregs) play a non-redundant role in control of
excessive immune responses, and defects in Tregs have been shown both in patients and …
excessive immune responses, and defects in Tregs have been shown both in patients and …
Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome
Introduction The lacrimal gland (LG) of the CD25-/-model of Sjögren's syndrome (SS) has
high interleukin (IL)-17, IL-13 and interferon-gamma (IFN-γ) cytokines. The specific …
high interleukin (IL)-17, IL-13 and interferon-gamma (IFN-γ) cytokines. The specific …
原发性胆汁性肝硬化的流行病学与自然史变迁.
王立峰， 李元元， 金磊， 王福生 - Journal of Clinical …, 2015 - search.ebscohost.com
原发性胆汁性肝硬化(PBC) 是一种自身免疫介导的胆汁淤积性肝病. 全面介绍了不同国家和不同
地区PBC 的流行病学情况, 并针对熊去氧胆酸药物广泛应用前后, PBC 自然史的变迁进行了分析 …
地区PBC 的流行病学情况, 并针对熊去氧胆酸药物广泛应用前后, PBC 自然史的变迁进行了分析 …
[HTML][HTML] Interferon-gamma deficiency protects against aging-related goblet cell loss
Aging is a well-recognized risk factor for dry eye. Interferon-gamma (IFN-γ) has been
implicated in conjunctival keratinization and goblet cell loss in dry eye. We investigated the …
implicated in conjunctival keratinization and goblet cell loss in dry eye. We investigated the …
IL-21, not IL-17A, exacerbates murine primary biliary cholangitis
CW Chan, HW Chen, YW Wang, CI Lin… - Clinical and …, 2024 - academic.oup.com
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease caused by
intrahepatic bile duct injuries, resulting in fibrosis, cirrhosis, and eventually liver failure. T …
intrahepatic bile duct injuries, resulting in fibrosis, cirrhosis, and eventually liver failure. T …
Metabolic and phenotypic differences between mice producing a Werner syndrome helicase mutant protein and WRN null mice
L Aumailley, C Garand, MJ Dubois, FB Johnson… - PloS one, 2015 - journals.plos.org
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family
DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit …
DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit …